Medicine Innovates Medicine Innovates: Delivering innovations in medicine to the world for better health and prosperity
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Peptide dendrimers as potentiators of conventional chemotherapy in the treatment of pancreatic cancer in a mouse model
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Polypharmacy decreases the survival probability of older colorectal cancer patients
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Screening for Functional Peptide Inhibitors of Transcription Factor Activity
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An Autophagy-Disrupting Small Molecule Promotes Cancer Cell Death via Caspase Activation
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Glioblastoma cell migration is directed by electrical signals
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The Use of Cerebrospinal Fluid in Medulloblastoma Biomarkers Studies
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Human DNAJA1 Protein: A Potential Novel Therapeutic Target for Pancreatic Cancer
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CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism
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Newly discovered neutrophil subset-specific targeted therapy for human inflammatory diseases
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Inclusion of Pregnant Individuals in Our Plans to Eliminate HCV
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Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2
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Diet – not only nutrition but also essential for education of the immune system
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Soluble CD40L activates soluble and cell-surface integrin αvβ3, α5β1, and α4β1 by binding to the allosteric ligand-binding site (site 2)
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Reduced allergic lung inflammation and airway responsiveness in mice lacking the cytoskeletal protein gelsolin
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Longitudinal monitoring of microglial/ macrophage activation in ischemic rat brain using Iba-1-specific nanoparticle enhanced MRI
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Two monomers of the complement deregulator FHR5 associate to form a compact dimer to provide new insights into CFHR5 nephropathy
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A potential gene therapy approach for long-term alleviation of neuropathic pain
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CITED2 inhibits STAT1-IRF1 signaling and atherogenesis
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Disease mechanisms of X- linked cone dystrophy caused by missense mutations in the red and green cone opsins
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Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a
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In vitro rejuvenation of osteoarthritis-affected human chondrocytes cultured in a polymer based 3D matrix, evidenced by enhanced miRNA expression
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Circadian control of heparan sulfate levels times clearance of amyloid beta aggregates
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Impact of endocrine-disrupting chemicals on steroidogenesis and consequences on testicular function
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Novel Endoxifen-Resistant Breast Cancer Cell Lines Highlight Numerous Differences from Tamoxifen-Resistant Models
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Heterogeneity of neutrophils in arterial hypertension
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Choline transporter-like proteins 1 and 2 are newly identified plasma membrane and mitochondrial ethanolamine transporters
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Mutations in EDA and EDAR genes cause dominant syndromic tooth agenesis
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Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues
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TMF1- A novel mediator of the Insulin regulated glucose homeostasis and normal glycemic level
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T cell-derived extracellular vesicles are elevated in essential Hypertension
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Skeletal muscle mitochondrial fragmentation and impaired bioenergetics from nutrient overload are prevented by carbon monoxide
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CAPS2 Deficiency in Autism Impairs the Release of the Social Peptide Oxytocin
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The relaxation effect of EOs is due to their effect on neuroreceptors and electroencephalographic rhythms – a study finds
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A basic model for cell cholesterol homeostasis
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Identification and biochemical characterization of a novel NAD+-dependent homoserine dehydrogenase from the symbiotic Polynucleobacter necessarius
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PINK1 has an alter ego: switching from controlling mitochondrial quality to stimulating neuronal plasticity through BDNF
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Revealing the Threat of Emerging SARS-CoV-2 Mutations to Antibody Therapies
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Burn calories! Fighting against obesity by activating beige fat development
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Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations
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Mass Spectrometric Enzyme Histochemistry for Choline Acetyltransferase Reveals De Novo Acetylcholine Synthesis in Rodent Brain and Spinal Cord
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Post-translocational modifications of HSP47 with myristoylation, farnesylation go to mitochondria after electron and X-ray irradiation
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The role of PPARγ in chemotherapy-evoked pain
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Eucommia ulmoides (Tochu) and its extract geniposidic acid reduced blood pressure and improved renal hemodynamics
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In Vitro Characterization and Metabolomic Analysis of Cold-Stored Platelets
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The µ-δ opioid heteromer masks latent pain sensitization in neuropathic and inflammatory pain in male and female mice
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The C-terminal domain of yeast Atg15 has an enzymatic activity that breaks lipid membranes of unnecessary organelles
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Mature viral cathepsin is required for release of viral occlusion bodies from Autographa californica multiple nucleopolyhedrovirus-infected cells
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Striatal and nigral muscarinic type 1 and type 4 receptors modulate levodopa-induced dyskinesia and striato-nigral pathway activation in 6-hydroxydopamine hemilesioned rats
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DCIR and its ligand NA2 regulate osteoclastogenesis and immune response– a study shows
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SUV39H2 epigenetic silencing controls fate conversion of epidermal stem and progenitor cells
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Antibiotic Treatment of Acute Graft vs. Host Disease: Stop Killing the Good Bacteria
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Enhancing human naive pluripotency induction
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Erythrocytes in the fetus have different origin from those after birth
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Development of new intermediate pluripotent stem cells
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Setting the criteria for totipotent stem cells
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Johns Hopkins researchers develop new way to deliver sight-saving gene therapy to the retina
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Bioengineer perfused human brain vascular network
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Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders
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A nanomedicine made with plant protein and caffeine-like drug offers hope to spinal cord injury patients
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Autophagy induction boosts biotherapeutic protein productivity in industrial cell cultures
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A vacuum-assisted, highly parallelized microfluidic array for performing multi-step digital assays
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Acetate overflow metabolism is crucial for a seam-less metabolic phase transition after glucose depletion in Escherichia coli
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Robustness of aerosol delivery of amikacin liposome inhalation suspension using the PARI eFlow® Technology
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Novel biomimetics promote dynamic cell-driven remodeling of their microenvironment
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Facial emotion training as an intervention in autism spectrum disorder: A meta-analysis of randomized controlled trials
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Algorithm detects early vascular disease using photos of the eye
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Repurposing PARP inhibitors for Cancer-Associated Sf3b1 Mutations
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Detection of cancer through simultaneous detection of serotonin and dopamine
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Trigging PCR test by Light Pulse
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Metabolomics meets lipidomics: Assessing the small molecule component of metabolism
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Carbon nanotube-based sensor developed as a rapid diagnostic for Covid-19 or other emerging pathogens
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Evaluation of 99mTc-CN5DG as a broad-spectrum SPECT probe for tumor imaging