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Significance Image credit: Cancer Res (2026). https://doi.org/10.1158/0008-5472.CAN-25-1992 Reference Adhikary U, Tesar B, Patel K, Schmidt …
Read More »Unsupervised Machine Learning Helps Discover Patterns of Racial Disparities in Breast Cancer Patients
Comprehensive Pancreatic Cancer Risk Prediction Model Integrating Genetic, Lifestyle, and Medical History Variables: Insights from the UK Biobank
Proteomic Profiling for Optimized Therapy Selection in Acute Myeloid Leukemia
Interleukin-12 Armored Myeloid-Targeted CAR-T Reprogram Tumor Immunity
Spatial Rewiring of Glyco-Immune Checkpoints for Precision Cancer Immunotherapy
Tumor-Stroma Interactions: How NSCLC and Radiotherapy Drive Resistance via MSC Senescence
Tri-Specific T-Cell Engagers for Glioblastoma: A Multivalent Immunotherapy Targeting Tumor Heterogeneity
Exploiting Transcription-Replication Collisions to Treat Pancreatic Cancer: AOH1996 as a Precision Vulnerability Drug
Decoding Glycosylation: A Quantitative Leap in Protein Glycoform Analysis
RRAS2: A Prognostic Biomarker Driving Postpartum Triple-Negative Breast Cancer
the Role of KCNB2 in SHH Medulloblastoma: A Path to Targeted Cancer Therapy
Targeting NPEPPS to Enhance Cisplatin Efficacy: A Pathway to Overcome Chemotherapy Resistance
Early Post-Infusion Absolute Lymphocyte Count as a Prognostic Marker in BCMA-Targeting CAR-T Therapy for Relapsed Multiple Myeloma
Propensity Score Matching Reveals Non-Significance of Male Sex as a Prognostic Factor in Differentiated Thyroid Cancer Post Iodine Treatment
Opposing Treg programs shape IL-17-dependent growth in colorectal cancer
Significance Reference Xiao Huang, Dan Feng, Sneha Mitra, Emma S. Andretta, Nima B. Hooshdaran, Aazam …
Read More »Tetramer-stabilized neuraminidase subunit vaccination and protection metrics in swine influenza challenge
Microglia Constrain Glioma Growth and Sustain CD8 T-Cell Immunity
Opposing regulatory T cell subsets shape IL-17–dependent colorectal tumor growth
Immunotherapy in Primary Mediastinal Undifferentiated Pleomorphic Sarcoma: A Promising Approach
Exosome-Powered Oncolytic Viruses Change the Game in Breast Cancer Treatment
Caspase-8 as a Cellular Gatekeeper: Restraining Coxiella burnetii Through Apoptosis and Cytokine Regulation
Lipid-Induced Paralysis of NK Cells in Ovarian Cancer Ascites: A Metabolic Immune Checkpoint
Trained Immunity via Saprophytic Leptospira Exposure Confers Protection Against Severe Leptospirosis
Lung-Resident Memory T Cells and Epithelial Antigen Presentation Drive Neutrophilic Asthma: A Pathway for Targeted Therapy
Persistent Peptidoglycan from Borrelia burgdorferi as a Hidden Driver of Post-Infectious Inflammation
Selective JAK1 Inhibition with Itacitinib Enhances Haploidentical Transplantation Outcomes by Mitigating GvHD and CRS
Dual Mechanisms of NF-κB Activation in DNA Damage Responses: Bridging Transcriptional Stress and Inflammation
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A Multi-Mineral Intervention as a Potential Mucosal Barrier Therapy in Ulcerative Colitis
Significance Reference Aslam MN, Turgeon DK, Appelman HD, Stidham R, McClintock S, Allen R, Moraga …
Read More » GATA5/ISL1 fibroblasts in myocardial infarction repair
Cellular Senescence as a Disease-Modifying Target in Temporal Lobe Epilepsy
Chemotherapy-Driven Aging: Lasting Impacts of Cancer Treatment on Biological Aging Markers in Breast Cancer Survivors
Disrupting Ribosome Biogenesis to Break Chemoresistance in Breast Cancer
Quantifying Cancer Risk in the Age of Routine CT: A National Projection of Diagnostic Radiation Harm
Breaking the Genetic Code of Mental Illness: How Shared Variants Shape Psychiatric Disorders
ATF6: A Double-Edged Sword in Lysosomal Regulation and Mutant TP53 Degradation in Cancer Cells
Fibulin-2: A Key Genetic Driver in Goldenhar Syndrome and Craniofacial Development
The Essential Role of the PA14 Domain in B4GALNT3 and the Regulatory Impact of LacdiNAc on N-Glycan Biosynthesis
Denitrosylation Control of Lipid Synthesis Through Cytoskeletal and Enzymatic Targets
β-Blockers as Potential Modulators of Huntington’s Disease Onset and Progression
Nav1.5-Mediated Sodium Influx Drives Breast Cancer Metastasis Through Glycolytic Acidification
Squalene Peroxidation in Acne Vulgaris: Linking Sebum Oxidation to Inflammation and Comedogenesis
Impact of APOE Locus on Aging-Related Mitochondrial Function in Alzheimer’s Disease and Longevity
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TDP43 Control of Mismatch Repair Gene Expression and Genome Stability
Significance Reference Vincent E Provasek, Albino Bacolla, Suganya Rangaswamy, Manohar Kodavati, Joy Mitra, Issa O …
Read More » Age-dependent ER remodeling through selective autophagy across tissues
Hyperoxia-Induced Modulation of Intrapulmonary Arteriovenous Anastomoses: from Saline Contrast Echocardiography
Nascent SKIK Peptide as a Minimal Module to Relieve Polyproline-Induced Ribosome Stalling and Enhance Translation Efficiency
Identification and Functional Characterization of RAB32 Ser71Arg: A Novel Genetic Variant Implicated in Familial Parkinson’s Disease
Pharmacologic Vitamin C Triggers Mitochondrial Collapse via ROS-Iron-Calcium Crosstalk in Human Osteosarcoma
Viral Mimicry Unveiled: How Ocr Sabotages the BREX System to Outsmart Bacterial Defenses
Uncovering a Hidden Risk: The Link Between CDK4/6 Inhibitors and Jaw Bone Health
Distinctive Hyaluronan Metabolism in Epidermal Keratinocytes: Roles of HYAL1 and HAS3
Protective Potential of IgE: How Allergy-Related Immune Responses Influence Glioma Risk and Survival
HOXDeRNA’s Role in Glioblastoma: Reprogramming Astrocytes via RNA-Driven Epigenetic Modulation
Soluble BCMA as a Key Mediator of Resistance in Anti-BCMA T-cell Therapies for Multiple Myeloma
Regulatory Dynamics of Enamelin Expression by Msx2 controlling Enamel Formation and Biomineralization
Daridorexant: Novel insomnia drug shows low abuse potential in comprehensive animal study
Characterization of PIH1D3 Deficiency in Knockout Rats: Insights into Ciliopathy Mechanisms and Phenotypic Manifestations
CT-KIBRA-mediated Synaptic Repair as a Therapeutic Strategy for Cognitive Restoration in Tauopathies
New Strategy for Bone Regeneration Leverages Cooperative Interactions between Collagen Receptors to Enhance Osteoblast Differentiation of Skeletal Progenitor Cells
Advancing Mesenchymal Stem Cell Therapies for Bronchopulmonary Dysplasia: Challenges and Prospects
Advancing Liver Regeneration: VEGFA mRNA-LNP’s Transformative Role in Hepatocyte Conversion
Reversible Quiescence in Adult Stem Cells: A Profound Insight into Tissue Regeneration and Disease
The Potential of Mesenchymal Stem Cells and Extracellular Vesicles in Osteoarthritis Pain Management
The Mysteries of Cell Rounding: AQUAPORINs and Hematopoietic Transition
Characterization of a melanocyte progenitor population in human interfollicular epidermis
PDGF D in the regulation of mesenchymal stem cell biology
Is metabolite N, N-dimethylglycine a candidate drug for peripheral nerve injury repair?
Lymphatics act as a signaling hub to regulate intestinal stem cell activity
Growth factor Igf2bp2 controls the function of blood stem cells in early life
Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling
Proliferation maintains the undifferentiated status of stem cells: The role of the planarian cell cycle regulator Cdh1
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Restoring Brain Resilience Reverses Advanced Alzheimer’s Disease Through NAD⁺ Homeostasis
Significance Reference Kalyani Chaubey, Edwin Vázquez-Rosa, Sunil Jamuna Tripathi, Min-Kyoo Shin, Youngmin Yu, Matasha Dhar, …
Read More » Epigenetic Clocks and Neurodegenerative Diseases
Acute taVNS Reduces Presynaptic SV2A Density in Key Brain Regions Without Altering Glucose Metabolism: A MicroPET Study in Healthy Rats
Redefining Clinical Trials for Neural Prostheses: Bridging Technological Innovation and Ethical Responsibility
Therapeutic Neuroplasticity: Reshaping Brain Networks in Convergence Insufficiency
Neuropilin-1: A Target for Redefining Chronic Pain Therapies Through Non-Opioid Mechanisms
Adaptive Deep Brain Stimulation for Real-Time Control of Parkinsonian Neural Dynamics: Toward Personalized Neuromodulation
HDAC3 Inhibition Restores Memory Updating in Aging: A Potential Therapeutic Target for Cognitive Decline
Neural Circuitry and Neurochemical Modulation in Cognitive Function
Shaping Minds: How Education Carves the Brain’s Landscape
The Key Role of p75NTR in Oligodendrocyte Genesis and Brain Myelination
Stress, Immunity, and Alzheimer’s Disease Progression: Studies in Transgenic Mouse Models
Synergistic Enhancement of BDNF-Mediated Neurotrophic Activities by Apigenin: Implications for Neurodegenerative Disease Therapy
Synergizing adoptive cell therapy: Boosting Cancer Cell Targeting with Dual TCR/CAR Engineering
CRISPR-ABE Mediated Correction of ASLD via Lipid Nanoparticle Delivery: A Novel Therapeutic Approach
Gene Therapy Rescues Neural Deficits in CNTNAP1 Mutant Mice
Gene Therapy in Sickle Cell Disease: Clonal Dynamics and Mutation Landscapes Post-Treatment
CRISPR Breakthrough: Targeting the Achilles’ Heel of AML – A Leap Towards Precision Oncology
New technology enables predictive design of engineered human cells
Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae
Machine-learning creates better AAV gene delivery vehicles
New Druggable Target for Pancreatic Cancer Discovered
GM-CSF therapy inhibits chronic graft-versus-host disease via expansion of regulatory T cells
