Medicine Innovates Medicine Innovates: Delivering innovations in medicine to the world for better health and prosperity
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New method for delivering proteins intracellularly offers a promising opportunity to target the undruggable proteome
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Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer
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Adipokine Apelin/APJ Pathway Promotes Peritoneal Dissemination of Ovarian Cancer Cells by Regulating Lipid Metabolism
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Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide
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Researchers characterize the 3D chromatin structure and segmented DNA methylation to understand its role in carcinogenesis
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p53 induces a survival transcriptional response after nucleolar stress
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Peptide dendrimers as potentiators of conventional chemotherapy in the treatment of pancreatic cancer in a mouse model
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Polypharmacy decreases the survival probability of older colorectal cancer patients
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Understanding the non-specific effects of BCG vaccination in babies – the expansion of Th17 cells in early life
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Development of an Oral Drug Targeting TAK1 as an Alternative to Front-line Biologics for Rheumatoid Arthritis
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Autophagy induction may help rescue thyroid cells from antibody induced cell death
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SGLT2 inhibitor counteracts NLRP3 inflammasome via tubular metabolite itaconate in fibrosis kidney
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Newly discovered neutrophil subset-specific targeted therapy for human inflammatory diseases
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Inclusion of Pregnant Individuals in Our Plans to Eliminate HCV
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Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2
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Diet – not only nutrition but also essential for education of the immune system
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Identification of defined structural elements within TOR2 kinase required for TOR complex 2 assembly and function in Saccharomyces cerevisiae
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Dysfunction of cerebellar microglia in Ataxia-telangiectasia
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A polypeptide model for toxic aberrant proteins induced by aminoglycoside antibiotics
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Cryptococcus neoformans melanization incorporates multiple catecholamines to produce polytypic melanin
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SORLA is needed for insulin-induced expansion of visceral adipocytes
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No association between hearing loss and amyloid-beta accumulation in the brain
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Neocortex enters a ‘low battery mode’ during food scarcity
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Activation of vitamin D receptor inhibits Tau phosphorylation is associated with reduction of iron accumulation in APP/PS1 transgenic mice
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First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein–Protein Interactions
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Why do the different positions of nitro groups in nitro-polycyclic aromatic hydrocarbons significantly affect their mutagenicity?
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Inhibition of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 by mosquito and mouse saliva
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Is early intervention the key to the prevention of posttraumatic epilepsy?
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Deficiency of M-LP/Mpv17L, a newly identified atypical phosphodiesterase, causes β-cell hyperplasia and improves glucose tolerance
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Why do tricyclic antidepressants relieve neuropathic pain?
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Exploring the role of glycoprotein hormone GPA2/GPB5 in the kiss of death bug, Rhodnius prolixus
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Effect of Cerebrospinal Fluid Circulation on Nose-to-Brain Direct Delivery and Distribution of Caffeine in Rats
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Lymphatics act as a signaling hub to regulate intestinal stem cell activity
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Growth factor Igf2bp2 controls the function of blood stem cells in early life
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Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling
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Proliferation maintains the undifferentiated status of stem cells: The role of the planarian cell cycle regulator Cdh1
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Lef-1 controls cell cycle progression in airway basal cells to regulate proliferation and differentiation
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DCIR and its ligand NA2 regulate osteoclastogenesis and immune response– a study shows
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SUV39H2 epigenetic silencing controls fate conversion of epidermal stem and progenitor cells
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Antibiotic Treatment of Acute Graft vs. Host Disease: Stop Killing the Good Bacteria