Medicine Innovates Medicine Innovates: Delivering innovations in medicine to the world for better health and prosperity
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Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide
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Researchers characterize the 3D chromatin structure and segmented DNA methylation to understand its role in carcinogenesis
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p53 induces a survival transcriptional response after nucleolar stress
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Peptide dendrimers as potentiators of conventional chemotherapy in the treatment of pancreatic cancer in a mouse model
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Polypharmacy decreases the survival probability of older colorectal cancer patients
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Screening for Functional Peptide Inhibitors of Transcription Factor Activity
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An Autophagy-Disrupting Small Molecule Promotes Cancer Cell Death via Caspase Activation
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Glioblastoma cell migration is directed by electrical signals
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Understanding the non-specific effects of BCG vaccination in babies – the expansion of Th17 cells in early life
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Development of an Oral Drug Targeting TAK1 as an Alternative to Front-line Biologics for Rheumatoid Arthritis
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Autophagy induction may help rescue thyroid cells from antibody induced cell death
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SGLT2 inhibitor counteracts NLRP3 inflammasome via tubular metabolite itaconate in fibrosis kidney
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Newly discovered neutrophil subset-specific targeted therapy for human inflammatory diseases
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Inclusion of Pregnant Individuals in Our Plans to Eliminate HCV
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Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2
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Diet – not only nutrition but also essential for education of the immune system
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A polypeptide model for toxic aberrant proteins induced by aminoglycoside antibiotics
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Cryptococcus neoformans melanization incorporates multiple catecholamines to produce polytypic melanin
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SORLA is needed for insulin-induced expansion of visceral adipocytes
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No association between hearing loss and amyloid-beta accumulation in the brain
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Neocortex enters a ‘low battery mode’ during food scarcity
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Activation of vitamin D receptor inhibits Tau phosphorylation is associated with reduction of iron accumulation in APP/PS1 transgenic mice
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Glial ER and GAP junction mediated Ca2+ waves play a vital role in maintaining brain excitability
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α-lipoic acid has the potential to normalize copper metabolism and prevent or treat Alzheimer’s disease
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Sex hormones matter: Reduced concentrations of vaginal metabolites involved in steroid hormone biosynthesis are associated with increased vulvar vestibular pain and vaginal muscle tenderness in provoked vestibulodynia
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A potential gene therapy approach for long-term alleviation of neuropathic pain
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CITED2 inhibits STAT1-IRF1 signaling and atherogenesis
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Disease mechanisms of X- linked cone dystrophy caused by missense mutations in the red and green cone opsins
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Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a
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In vitro rejuvenation of osteoarthritis-affected human chondrocytes cultured in a polymer based 3D matrix, evidenced by enhanced miRNA expression
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Circadian control of heparan sulfate levels times clearance of amyloid beta aggregates
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Impact of endocrine-disrupting chemicals on steroidogenesis and consequences on testicular function
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Deficiency of M-LP/Mpv17L, a newly identified atypical phosphodiesterase, causes β-cell hyperplasia and improves glucose tolerance
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Why do tricyclic antidepressants relieve neuropathic pain?
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Exploring the role of glycoprotein hormone GPA2/GPB5 in the kiss of death bug, Rhodnius prolixus
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Effect of Cerebrospinal Fluid Circulation on Nose-to-Brain Direct Delivery and Distribution of Caffeine in Rats
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IGF2-H19 ICR1 imprinting loss enhances endocrine capacity via sex-specific alterations pathways in mouse
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Calcium gives the final touch to the formation of functional endothelial barriers
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The relaxation effect of EOs is due to their effect on neuroreceptors and electroencephalographic rhythms – a study finds
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A basic model for cell cholesterol homeostasis
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Identification and biochemical characterization of a novel NAD+-dependent homoserine dehydrogenase from the symbiotic Polynucleobacter necessarius
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PINK1 has an alter ego: switching from controlling mitochondrial quality to stimulating neuronal plasticity through BDNF
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Revealing the Threat of Emerging SARS-CoV-2 Mutations to Antibody Therapies
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Burn calories! Fighting against obesity by activating beige fat development
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Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations
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Mass Spectrometric Enzyme Histochemistry for Choline Acetyltransferase Reveals De Novo Acetylcholine Synthesis in Rodent Brain and Spinal Cord
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Post-translocational modifications of HSP47 with myristoylation, farnesylation go to mitochondria after electron and X-ray irradiation
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The role of PPARγ in chemotherapy-evoked pain
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Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling
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Proliferation maintains the undifferentiated status of stem cells: The role of the planarian cell cycle regulator Cdh1
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Lef-1 controls cell cycle progression in airway basal cells to regulate proliferation and differentiation
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DCIR and its ligand NA2 regulate osteoclastogenesis and immune response– a study shows
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SUV39H2 epigenetic silencing controls fate conversion of epidermal stem and progenitor cells
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Antibiotic Treatment of Acute Graft vs. Host Disease: Stop Killing the Good Bacteria
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Enhancing human naive pluripotency induction
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Erythrocytes in the fetus have different origin from those after birth
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Cov_DOX: A Method for Structure Prediction of Covalent Protein- Ligand Bindings
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Effect of patient inhalation profile and airway structure on drug deposition in image-based models with particle-particle interactions
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De Novo Biosynthesis of D‑p‑Hydroxyphenylglycine by a Designed Cofactor Self-Sufficient Route and Co-culture Strategy
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Lipid-Coated CaCO3 Nanoparticles as Tumor Acidity Responsive Nanocarriers
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Systematic assessment of process analytical technologies for biologics
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Heme oxygenase-1 gene delivery for altering high mobility group box-1 protein in pancreatic islet
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“Four-in-one” strategy for aspartic acid-assisted nanoscale spherical COFs controllable synthesis and biological application
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TissueNexus: a bodymap of human gene networks across 49 tissues or cell lines may help understand diseases better
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An automated and mobile magnetoresistive biosensor system for early hepatocellular carcinoma diagnosis
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The Auditory Afferent Pathway as a Clinical Marker of Alzheimer’s Disease
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Aseptic Femoral Head Destruction
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4-Amino-1, 8-naphthalimide-ferrocene conjugates as multi-targeted anticancer and fluorescent cellular imaging agents
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Facial emotion training as an intervention in autism spectrum disorder: A meta-analysis of randomized controlled trials
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Algorithm detects early vascular disease using photos of the eye
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Repurposing PARP inhibitors for Cancer-Associated Sf3b1 Mutations
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Detection of cancer through simultaneous detection of serotonin and dopamine