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DISEASE UNDERSTANDING
MECHANISM OF ACTION
DIAGNOSTICS
REGENERATIVE MEDICINE
BREAKTHROUGH
CANCER
IMMUNOLOGY
GENE THERAPY
DRUG DISCOVERY
NEUROSCIENCE
PRECISION MEDICINE

Jeffery M. Klco, MD, PhD

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Breakthrough Technologies

A Streamlined Protocol for mRNA Lipid Nanoparticle Development: Bridging Innovation and Accessibility in Genetic Medicine
3 days ago
Adaptive Open Fluidics: Particle-Stabilized Liquid Channels for Biomedical and Chemical Applications
6 days ago
Engineered Immunological Niches and Antigen-Specific Nanoparticles: A Targeted Approach to Treating Progressive Multiple Sclerosis
1 week ago
Charge Complementary Polymersomes: Advancing Stability and Delivery Efficiency in mRNA Therapeutics
2 weeks ago
Decoding Immune Interactions in Acute Myeloid Leukemia
2 weeks ago
Guided SEFFI and CaHA: A Transformative Approach to Regenerative Facial Rejuvenation
3 weeks ago
Harnessing Light for Precision Gene Regulation: The OptoLacI Breakthrough
3 weeks ago
Translation-Coupled mRNA Decay: The Role of m6A Modifications in Fine-Tuning Gene Expression
3 weeks ago
Wireless Multicolor Fluorescence Imaging Implant for Real-Time Monitoring of Immune Responses in Cancer Therapy
3 weeks ago
Nonlinear Molecular Dynamics Reveal Critical Transitions in Human Aging and Disease Risk
3 weeks ago
Inhomogeneous Au2S Nanostructures for Enhanced Dual-Function Tumor Imaging and Therapy via Targeted Energy Dissipation
3 weeks ago
Accessible Rheo-Optical Compression Assay for High-Throughput Mechanical Characterization of Cell Spheroids
4 weeks ago

Diagnostics

Decoding PRDM16-DT: A Hidden Protein Regulating Colorectal Cancer Metastasis and Chemoresistance
3 days ago
Correlation Between Autonomic Dysfunction and Visual Field Severity in Open-Angle Glaucoma: Insights from Kiritsu-Meijin Device Analysis
1 week ago
Serum Biomarkers and Neuroimaging Correlates in CT-Negative Mild Traumatic Brain Injury
1 week ago
Advancement in Cancer Detection: A Leap Forward with Novel Priming Agents in Liquid Biopsies
2 weeks ago
Advancing Cancer Detection: Engineered Bacteria as Living Biosensors
2 weeks ago
Accelerating Precision Medicine in Antimicrobial Therapy: The MultiRapid ATB NP Test for Combatting Multidrug-Resistant Enterobacterales
2 weeks ago
Pharmacogenetics in Elderly CAD Patients: A Path Toward Personalized Cardiovascular Therapy
2 weeks ago
Innovative Pulmonary Imaging: 3D UTE-MRI Ventilation and Flow Mapping for Enhanced Lung Function Analysis
3 weeks ago

Drug Discovery

Targeting OprF to Overcome Carbapenem Resistance in Pseudomonas aeruginosa: A New Therapeutic Opportunity
1 week ago
Targeted Antimicrobial Therapies: Harnessing Niche-Specific Metabolic Vulnerabilities in Pathogens
2 weeks ago
Transforming Oral Cancer Therapies: Enhanced Bioavailability and Reduced Variability with Innovative Drug Formulations
2 weeks ago
Transforming Bioequivalence Assessment with the Finite Absorption Time Concept
2 weeks ago
Targeting EGFR Drug Resistance in NSCLC: Identification of Alternative Inhibitors through Structural Analysis and Virtual Screening
3 weeks ago
RY103: A Novel IDO1 Inhibitor Targeting Immune Suppression and Angiogenesis in Glioblastoma Therapy
3 weeks ago
Unexpected Impact of Roxadustat on Thyroid Function: New Insights into HIF-PH Inhibitors in Renal Anemia
3 weeks ago
Splicing modulating small molecules perturb the entire transcriptome: implications for developing next generation therapies for spinal muscular atrophy
3 weeks ago

Translational Medicine

RRAS2: A Prognostic Biomarker Driving Postpartum Triple-Negative Breast Cancer
3 weeks ago
Accessible Rheo-Optical Compression Assay for High-Throughput Mechanical Characterization of Cell Spheroids
4 weeks ago
Comprehensive Pancreatic Cancer Risk Prediction Model Integrating Genetic, Lifestyle, and Medical History Variables: Insights from the UK Biobank
4 weeks ago
Unsupervised Machine Learning Helps Discover Patterns of Racial Disparities in Breast Cancer Patients
4 weeks ago
Hyperoxia-Induced Modulation of Intrapulmonary Arteriovenous Anastomoses: from Saline Contrast Echocardiography
January 26, 2025

Precision Medicine

Correlation Between Autonomic Dysfunction and Visual Field Severity in Open-Angle Glaucoma: Insights from Kiritsu-Meijin Device Analysis
1 week ago
Serum Biomarkers and Neuroimaging Correlates in CT-Negative Mild Traumatic Brain Injury
1 week ago
Charge Complementary Polymersomes: Advancing Stability and Delivery Efficiency in mRNA Therapeutics
2 weeks ago
Advancement in Cancer Detection: A Leap Forward with Novel Priming Agents in Liquid Biopsies
2 weeks ago
Advancing Cancer Detection: Engineered Bacteria as Living Biosensors
2 weeks ago

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