Lignocellulose based analytical devices: bamboo as an analytical platform for chemical detection

Lignocellulose-based-analytical-devices-bamboo-analytical-platform-chemical detection

Journal Reference

Sci Rep. 2015 Dec 21;5:18570. doi: 10.1038/srep18570.

Kuan CM1, York RL2,3, Cheng CM4.

[expand title=”Show Affiliations”]
  1. Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 30013, Taiwan.
  2. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
  3. Department of Anesethesiology, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
  4. Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.



This article describes the development of lignocellulose-based analytical  devices (LADs) for rapid bioanalysis in low-resource settings. lignocellulose-based analytical devices are constructed using either a single lignocellulose or a hybrid design consisting of multiple types of lignocellulose. lignocellulose-based analytical devices are simple, low-cost, easy to use, provide rapid response, and do not require external instrumentation during operation. Here, we demonstrate the implementation of lignocellulose-based analytical devices for food and water safety (i.e., nitrite assay in hot-pot soup, bacterial  detection in water, and resazurin assay in milk) and urinalysis (i.e., nitrite, urobilinogen, and pH assays in human urine). Notably, we created a unique approach using simple chemicals to achieve sensitivity similar to that of commercially available immunochromatographic strips that is low-cost, and provides on-site, rapid detection, for instance, of Eschericia coli (E. coli) in water.

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