Significance Figure 1. The overall scheme of CYC_BUILDER Reference Wang F, Zhang T, Zhu J, Zhang X, Zhang C, Lai L. Reinforcement Learning-Based Target-Specific De Novo Design of Cyclic Peptide Binders. J Med Chem. 2025;68(16):17287-17302. doi: 10.1021/acs.jmedchem.5c00789.
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Significance Reference Cheng S, Liao J, Chen Z, Li F, Zhu Y, Zhang J, Guan D. Novel Rationally Designed Lipopeptides Derived from Bacitracin: Combating Multidrug Resistance and Evading Bacitracin Resistance via Potentiated Cell Wall and Membrane Inhibitions. J Med Chem. 2025;68(15):16410-16426. doi: 10.1021/acs.jmedchem.5c01285.
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Significance Figure: Metascape analysis demonstrated down-regulation of immune response, inflammation, microglial phagocytosis, and cell migration pathways after 24:5n-3 supplementation. The network plot visualizes functionally grouped enriched terms, where each node represents a biological pathway or process. Node size reflects the number of genes associated with each term, and node color indicates statistical significance, with darker colors representing lower P values. Image credit: …
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