Cancer

Significance  Image credit: Cancer Res (2026). https://doi.org/10.1158/0008-5472.CAN-25-1992 Reference Adhikary U, Tesar B, Patel K, Schmidt MJ, Levy HR, Zacharakis E, Godes M, Gokhale PC, Hebert KM, Neuberg DS, Bird GH, Walensky LD. Cancer Susceptibility to Stapled Oncolytic Peptides is Dictated by Membrane Cholesterol and Inflammatory Signaling. Cancer Res. 2026 Mar 5. doi: 10.1158/0008-5472.CAN-25-1992.

Significance  Reference Mateus-Tique J, Lakshmi A, Singh B, Iyer R, Sánchez-Paulete AR, Falcomatà C, Lin M, Pantsulaia G, Tepper A, Nguyen T, Amabile A, Mollaoglu G, Pia L, Chhamalwan D, Le Berichel J, Potak H, Colonna M, Baccarini A, Brody J, Merad M, Brown BD. Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth. …

Significance  Reference Jessica Stark, Melissa Gray, Itziar Ibarlucea-Benitez, Marta Lustig, Annalise Bond, Brian Cho, Ishika Govil, Tran Luu, Megan Priestley, Tim Veth, Wesley Errington, Bence Bruncsics, Mikaela Ribi, Leo Williams, Casim Sarkar, Simon Wisnovsky, Nicholas M. Riley, Meghan Morrissey, Thomas Valerius, Jeffrey Ravetch, Carolyn Bertozzi. Antibody-lectin chimeras for glyco-immune checkpoint blockade. Nature Biotechnology, 2025; DOI: 10.1038/s41587-025-02884-6