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RRAS2: A Prognostic Biomarker Driving Postpartum Triple-Negative Breast Cancer
Unsupervised Machine Learning Helps Discover Patterns of Racial Disparities in Breast Cancer Patients
Comprehensive Pancreatic Cancer Risk Prediction Model Integrating Genetic, Lifestyle, and Medical History Variables: Insights from the UK Biobank
Proteomic Profiling for Optimized Therapy Selection in Acute Myeloid Leukemia
Interleukin-12 Armored Myeloid-Targeted CAR-T Reprogram Tumor Immunity
Significance Reference Mateus-Tique J, Lakshmi A, Singh B, Iyer R, Sánchez-Paulete AR, Falcomatà C, Lin M, Pantsulaia G, Tepper A, Nguyen T, Amabile A, Mollaoglu G, Pia L, Chhamalwan D, Le Berichel J, Potak H, Colonna M, Baccarini A, Brody J, Merad M, Brown BD. Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth. …
Read More »Spatial Rewiring of Glyco-Immune Checkpoints for Precision Cancer Immunotherapy
Significance Reference Jessica Stark, Melissa Gray, Itziar Ibarlucea-Benitez, Marta Lustig, Annalise Bond, Brian Cho, Ishika Govil, Tran Luu, Megan Priestley, Tim Veth, Wesley Errington, Bence Bruncsics, Mikaela Ribi, Leo Williams, Casim Sarkar, Simon Wisnovsky, Nicholas M. Riley, Meghan Morrissey, Thomas Valerius, Jeffrey Ravetch, Carolyn Bertozzi. Antibody-lectin chimeras for glyco-immune checkpoint blockade. Nature Biotechnology, 2025; DOI: 10.1038/s41587-025-02884-6
Read More »Tumor-Stroma Interactions: How NSCLC and Radiotherapy Drive Resistance via MSC Senescence
Tri-Specific T-Cell Engagers for Glioblastoma: A Multivalent Immunotherapy Targeting Tumor Heterogeneity
Exploiting Transcription-Replication Collisions to Treat Pancreatic Cancer: AOH1996 as a Precision Vulnerability Drug
Decoding Glycosylation: A Quantitative Leap in Protein Glycoform Analysis
