Disease Understanding

Significance  Reference Aslam MN, Turgeon DK, Appelman HD, Stidham R, McClintock S, Allen R, Moraga G, Harber I, Jencks KJ, McNeely MM, Sen A, Jepsen KJ, Varani J. A multi-mineral intervention to improve disease-related and mechanistic biomarkers in ulcerative colitis patients: Results from a randomized trial. PLoS One. 2025;20(12):e0337408. doi: 10.1371/journal.pone.0337408. 

Significance  Reference Zhang S, Xiang B, Zhao Y, Wang W, Chen L, Zhou X. Single-cell epigenomic and transcriptomic analysis unveils the pivotal role of GATA5/ISL1+ fibroblasts in cardiac repair post-myocardial infarction. Cardiovasc Res. 2025;121(9):1419-1432. doi: 10.1093/cvr/cvaf101.

Significance  Figure legend: The protein denitrosylase SCoR2 regulates lipogenesis and fat storage Reference Venetos NM, Stomberski CT, Zhou HL, Qian Z, McLaughlin PJ, Bansal PK, Feczko J, Bederman I, Nguyen H, Hausladen A, Schindler JC, Grimmett ZW, Brunengraber H, Premont RT, Stamler JS. The protein denitrosylase SCoR2 regulates lipogenesis and fat storage. Sci Signal. 2025 Dec 23;18(918):eadv0660. doi: 10.1126/scisignal.adv0660.

Significance  Reference Tahiyana Khan, David J. McFall, Abbas I. Hussain, Logan A. Frayser, Timothy P. Casilli, Meaghan C. Steck, Irene Sanchez‐Brualla, Noah M. Kuehn, Michelle Cho, Jacqueline A. Barnes, Brent T. Harris, Stefano Vicini, Patrick A. Forcelli. Senescent Cell Clearance Ameliorates Temporal Lobe Epilepsy and Associated Spatial Memory Deficits in Mice. Annals of Neurology, 2025; DOI: 10.1002/ana.78118