Disease Understanding

A Multi-Mineral Intervention as a Potential Mucosal Barrier Therapy in Ulcerative Colitis

Significance  Reference Aslam MN, Turgeon DK, Appelman HD, Stidham R, McClintock S, Allen R, Moraga G, Harber I, Jencks KJ, McNeely MM, Sen A, Jepsen KJ, Varani J. A multi-mineral intervention to improve disease-related and mechanistic biomarkers in ulcerative colitis patients: Results from a randomized trial. PLoS One. 2025;20(12):e0337408. doi: 10.1371/journal.pone.0337408. 

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GATA5/ISL1 fibroblasts in myocardial infarction repair

Significance  Reference Zhang S, Xiang B, Zhao Y, Wang W, Chen L, Zhou X. Single-cell epigenomic and transcriptomic analysis unveils the pivotal role of GATA5/ISL1+ fibroblasts in cardiac repair post-myocardial infarction. Cardiovasc Res. 2025;121(9):1419-1432. doi: 10.1093/cvr/cvaf101.

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Cellular Senescence as a Disease-Modifying Target in Temporal Lobe Epilepsy

Significance  Reference Tahiyana Khan, David J. McFall, Abbas I. Hussain, Logan A. Frayser, Timothy P. Casilli, Meaghan C. Steck, Irene Sanchez‐Brualla, Noah M. Kuehn, Michelle Cho, Jacqueline A. Barnes, Brent T. Harris, Stefano Vicini, Patrick A. Forcelli. Senescent Cell Clearance Ameliorates Temporal Lobe Epilepsy and Associated Spatial Memory Deficits in Mice. Annals of Neurology, 2025; DOI: 10.1002/ana.78118

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