Immunology

Opposing Treg programs shape IL-17-dependent growth in colorectal cancer

Significance  Reference Xiao Huang, Dan Feng, Sneha Mitra, Emma S. Andretta, Nima B. Hooshdaran, Aazam P. Ghelani, Eric Y. Wang, Joe N. Frost, Victoria R. Lawless, Aparna Vancheswaran, Qingwen Jiang, Cheryl Mai, Karuna Ganesh, Christina S. Leslie, Alexander Y. Rudensky. Opposing functions of distinct regulatory T cell subsets in colorectal cancer. Immunity, 2026; 59 (1): 145 DOI: 10.1016/j.immuni.2025.11.014

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Tetramer-stabilized neuraminidase subunit vaccination and protection metrics in swine influenza challenge

Significance  FIGURE:  Structure prediction of rNA protein using SWISS-MODEL..  Vaccines (Basel). 2025;13(8):783. doi: 10.3390/vaccines13080783. Reference Zhang A, Tan B, Wang J, Zhang S. Recombinant Tetrameric Neuraminidase Subunit Vaccine Provides Protection Against Swine Influenza A Virus Infection in Pigs. Vaccines (Basel). 2025;13(8):783. doi: 10.3390/vaccines13080783.

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Microglia Constrain Glioma Growth and Sustain CD8 T-Cell Immunity

Significance        Reference Sun TC, Yu CF, Wu SY, Cheng WC, Chiang CS, Chen FH. Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T-cell immunity. Mol Oncol. 2025;19(9):2670-2685. doi: 10.1002/1878-0261.70102.

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Opposing regulatory T cell subsets shape IL-17–dependent colorectal tumor growth

Significance  Reference Huang X, Feng D, Mitra S, Andretta ES, Hooshdaran NB, Ghelani AP, Wang EY, Frost JN, Lawless VR, Vancheswaran A, Jiang Q, Mai C, Ganesh K, Leslie CS, Rudensky AY. Opposing functions of distinct regulatory T cell subsets in colorectal cancer. Immunity. 2026 Jan 13;59(1):145-160.e9. doi: 10.1016/j.immuni.2025.11.014.

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